NMN can increase muscle strength and improve mobility?
In the past, animal studies have found that supplementing with NMN, the precursor molecule of NAD+ can increase the level of NAD+ in the body. The decline in NAD+ levels that increase with age has been found to be related to cardiovascular disease, neurodegeneration, decreased muscle function, and other metabolic diseases. Studies have found that supplementing rodents with NMN may improve the above-mentioned aging conditions, but there are not much research data on NMN in humans. This study hopes to determine whether long-term use of NMN supplements can increase human blood NAD+ levels and improve some human age-related diseases.
YAMAUCHI Toshimasa of the University of Tokyo The professor and his team published a research article and found that healthy men over the age of 65 who participated in the study had a well-tolerated oral administration of 250 milligrams of NMN per day for 6 or 12 weeks, and increased the level of NAD+ and its related metabolites in the blood. Enhance muscle strength and improve mobility.
Research object standards
Inclusion criteria:
- Male
- 65 years and older
- BMI (kg/m2) 22-28
- Non-smokers
- Does not suffer from any disease
Exclusion criteria:
- Have a malignant tumor
- History of treatment of heart failure or emyocardial infarction
- Using prescription drugs or supplements ethat may affect clinical research
- People who exercise at least one hour a eday for at least six months
Research nature and safety
The study is a placebo-controlled, randomized, double-blind (participants and data collectors are unaware of the treatment), parallel-group trial. 42 men over 65 were randomly divided into 2 groups. The NMN group took 250 mg of NMN daily for 6 or 12 weeks (n=21 for 6 weeks; n=10 for 12 weeks); the control group took a placebo (n=21).
The compliance of the study treatment was very good, with all participants taking more than 90% of all NMN and placebo supplements. No serious adverse reactions were found in the study. Participants will collect whole blood at the beginning of the study (baseline) and at the twelfth week. In terms of hematology and blood chemistry, no significant differences were observed between the NMN group and the placebo group, including liver enzymes and renal function markers, while all clinical laboratory values in the NMN group remained within the normal range. These results support those healthy elderly men are well tolerated by supplementing 250 mg of NMN per day for 12 weeks.
Research findings and results
Oral administration of NMN for 12 weeks significantly increased the levels of human blood NMN, NAD+ and NAD+ related metabolites such as nicotinamide riboside (NR), nicotinic acid mononucleotide (NAMN) and nicotinic acid riboside (NAR). These findings show that long-term oral NMN supplementation can effectively stimulate NAD+ metabolism in healthy elderly men.
Long-term oral administration of NMN can help strengthen muscle strength and improve mobility. The research subjects have improved the number of times to get up from a chair and walking speed within 30 seconds (measured twice gait speed within a 10-meter walking time, and measured both The average value of each measurement is used as the result data), left-hand grip strength (repeated measurement twice for each hand, and the highest grip strength value is used as the result data).
In conclusion, oral NMN is well tolerated by elderly men, and it can also increase blood NAD+ and its related metabolites. In addition, NMN can also increase muscle strength and improve mobility. Researchers hope that oral NMN can help improve human muscle problems caused by aging, such as sarcopenia.